The locality is situated in Dunavăţ Plain, which is an alluvial plain forming the lowest seacoast step (3-5 m).

Murighiol village is placed into a lakes zone. It is almost surrounded by lakes: Murighiol I Lake at the northeastern part, Murighiol II Lake at the eastern part (both are fresh water lakes, supplied by Sfântu Gheorghe branch), Sărat Lake and Beibugeac Lake at the southern and southwestern part, forming together Sărăturile Murighiol.

Sărăturile Murighiol is surrounded by paludous vegetation (reed, bulrush) which ensure good nesting conditions for birds. They constitute also one of the ecological zones known for the protection of the aquatic birds preferring swampy habitat: avocet, black tailed godwit, black winged stilt, pink-footed goose, bean goose.

Murighiol village is also situated nearby the km 65 of Sfântu Gheorghe branch which is the oldest and the most sinuous Danube branch (113 km long). This branch has the most spectacular and the less affected by human activities impact landscape. Crossing the branch, at about 5 km upstream on the right side, Uzlina village can be found. This village is situated in the proximity of Uzlina Lake which is one of Danube Delta ecological reserves with ornithological importance.

The climate is influenced by the Danube proximity. Winter is mild (average temperature: -0.4°C) and summer is warm (average temperature: 21.6°C) and the year average temperature is 11°C. The year average quantity of precipitations is 444.5 mm.

Nowadays, the nature is not affected by any pollution or human factor.